File Name: ba f3 cells and their use in kinase drug discovery .zip
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Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique.
They are caused by chromosomal translocations that disrupt and constitutively activate FGFR1 8p11 by fusion to diverse partner genes. The only curative treatment at the moment is allogeneic stem cell transplantation. A year old female patient from Romania requested a second opinion on an outpatient basis. Peripheral blood examination showed anemia Hb The blast immunophenotype indicated a pre-T lymphoblastic leukemia. She refused a repeat bone marrow examination. She died elsewhere of septicemia in aplasia after a first course of high-dose chemotherapy.
Kinase enzymes are an important class of drug targets, particularly in cancer. Cell-based kinase assays are needed to understand how potential kinase inhibitors act on their targets in a physiologically relevant context. Current cell-based kinase assays rely on antibody-based detection of endogenous substrates, inaccurate disease models, or indirect measurements of drug action. Here we expand on previous work from our lab to introduce a well plate compatible approach for measuring cell-based kinase activity in disease-relevant human chronic myeloid leukemia cell lines using an exogenously added, multi-functional peptide substrate. Our cellular models natively express the BcrAbl oncogene and are either sensitive or have acquired resistance to well-characterized BcrAbl tyrosine kinase inhibitors.
Ba/F3 cells are an increasingly popular tool in kinase drug discovery. The ability to test the transforming capacity of newly identified kinase mutations, and to.
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Skip to main content. Search form Search. Eai fda. Retrieved 20 December Wang, Y.
These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
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Request PDF | Ba/F3 cells and their use in kinase drug discovery | Due to their ability to function as dominant oncogenes, protein kinases have.