neuronal dynamics from single neurons to networks and models of cognition pdf Thursday, April 29, 2021 4:02:59 PM

Neuronal Dynamics From Single Neurons To Networks And Models Of Cognition Pdf

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Neuronal Dynamics and Brain Connectivity

Biological neural networks produce information backgrounds of multi-scale spontaneous activity that become more complex in brain states displaying higher capacities for cognition, for instance, attentive awake versus asleep or anesthetized states. Here, we review brain state-dependent mechanisms spanning ion channel currents microscale to the dynamics of brain-wide, distributed, transient functional assemblies macroscale. Not unlike how microscopic interactions between molecules underlie structures formed in macroscopic states of matter, using statistical physics, the dynamics of microscopic neural phenomena can be linked to macroscopic brain dynamics through mesoscopic scales. Beyond spontaneous dynamics, it is observed that stimuli evoke collapses of complexity, most remarkable over high dimensional, asynchronous, irregular background dynamics during consciousness. In contrast, complexity may not be further collapsed beyond synchrony and regularity characteristic of unconscious spontaneous activity.

Wulfram Gerstner born in Heilbronn is a German and Swiss computational neuroscientist. His research focuses on neural spiking patterns in neural networks, and their connection to learning, spatial representation and navigation. In , he received his Master's degree with a thesis in experimental quantum optics. He then joined the theoretical biophysics group of William Bialek at University of California, Berkeley as a visiting researcher. He did postdoctoral work at Brandeis University [4] and at Technical University of Munich , [5] where he worked in theoretical neuroscience. In , he was nominated as assistant professor and in February he was promoted as an associate professor with tenure at EPFL. Gerstner's research is focused on models of spiking neurons , [7] [8] spike-timing-dependent plasticity STDP , [9] [10] [11] neuronal coding in single neurons and neuron populations.

What happens in our brain when we make a decision? What triggers a neuron to send out a signal? What is the neural code? This textbook for advanced undergraduate and beginning graduate students provides a thorough and up-to-date introduction to the fields of computational and theoretical neuroscience. The book covers classical topics, including the Hodgkin-Huxley equations and Hopfield model, as well as modern developments in the field such as Generalized Linear Models and decision theory.

Free eBook: Neuronal Dynamics

We explore and analyze the nonlinear switching dynamics of neuronal networks with non-homogeneous connectivity. The general significance of such transient dynamics for brain function is unclear; however, for instance decision-making processes in perception and cognition have been implicated with it. The network under study here is comprised of three subnetworks of either excitatory or inhibitory leaky integrate-and-fire neurons, of which two are of the same type. The synaptic weights are arranged to establish and maintain a balance between excitation and inhibition in case of a constant external drive. Each subnetwork is randomly connected, where all neurons belonging to a particular population have the same in-degree and the same out-degree. Neurons in different subnetworks are also randomly connected with the same probability; however, depending on the type of the pre-synaptic neuron, the synaptic weight is scaled by a factor.

Many circuits of the brain can be described by a system of interacting neural populations that are approximately homogeneous. For instance, cortical layers typically consist of a few main types of excitatory and inhibitory neurons that form small homogeneous populations of neurons. Such systems can be modeled on different spatial scales. On the microscopic scale, single cell activity has been faithfully described by reduced phenomenological neuron models [ 1 ]. Simulations of networks of such neuron models are, however, computationally expensive and do not offer much analytical insight. On the other hand, mesoscopic population models are reduced descriptions of the global activities of each population. These activities are stochastic due to the finite sizes of the populations.

Bridging Single Neuron Dynamics to Global Brain States

Jellyfish nerve nets provide insight into the origins of nervous systems, as both their taxonomic position and their evolutionary age imply that jellyfish resemble some of the earliest neuron-bearing, actively-swimming animals. Here, we develop the first neuronal network model for the nerve nets of jellyfish. Specifically, we focus on the moon jelly Aurelia aurita and the control of its energy-efficient swimming motion.

Neuronal Dynamics

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